Demand is rapidly escalating for higher-performing, more energy-efficient memory and storage for applications ranging from mobile devices to the cloud. This has serious implications for the open server platform. DRAM faces a major overhaul that will demand new system architectures. Meanwhile, V-NAND, a vertical 3-D NAND flash technology, is offering both higher endurance and smaller cell sizes, in leading the way to substantive changes in system design. Furthermore, other technologies are on the horizon that together will enable a new generation of “persistent” memory devices. They will have even higher performance than today’s devices and will enable a new tier in both memory and storage architectures.